University of British Columbia/BC Children's Hospital Research Institute
Our laboratory is focused on understanding how islet beta cells normally function and how they become dysfunctional in diabetes, and following transplantation. We have interests in understanding the mechanisms that lead to beta cell failure in type 2 diabetes, including the role of islet amyloid and islet inflammation. We are exploring the role of islet macrophages as contributors to both beta cell dysfunction and regeneration in diabetes. We also study IAPP, which is a trigger of islet inflammation, and its precursor proIAPP, which we believe is a biomarker of beta cell function in humans with type 1 diabetes.