Our lab has two main interests. First is understanding the circadian regulation of insulin secretion. Insulin secretion capacity varies throughout the day and we are interested in understanding the intrinsic mechanisms of the beta cell that regulate dynamic cycles of insulin secretion capacity and how this is impacted by circadian disruption, contributing to diabetes risk. Secondly, we are studying gene-environment interactions and impact on islet function. Indigenous children of Manitoba are disproportionately affected by type 2 diabetes. We have several ongoing projects to examine how genes and environment relevant to these children interact to impact islet function and diabetes development.