Montreal Clinical Research Institute (IRCM)
Our research focuses on understanding the pathogenesis of diabetes at the molecular level. We know that metabolic abnormalities in one tissue often impact the health of another (organ cross-talk), adding layers of complexity. In our lab, we strive to understand the molecular events in each tissue that trigger disease in the islet, and identify new ways to prevent, diagnosis, or reverse the metabolic abnormalities associated with insulin resistance and beta-cell dysfunction / death. To achieve our goals, we use tools in genetic engineering, molecular biology and physiology in vitro cell models to pre-clinical animal and small clinical studies.