Lab Interests:
Our laboratory uses a variety of technical approaches, from live-cell imaging to integrated physiology to multi-omics, to study islet biology and the roles of insulin throughout the body. Ongoing projects include sex differences in insulin production and ER stress, examining beta-cell stress and insulin production in early stage T1D, beta-cell stress adaptation, role of specific Ca release in beta-cell function, Scn9a in T1D, autocrine insulin action in beta-cell specific insulin resistance, role of macro-nutrient as secretagogues in human islets, spatio-temporal dynamics of insulin gene transcription, and the role of insulin in metabolic dysfunction.