University of Toronto
We are interested in the development and application of tools to measure cellular metabolism in tissue. Our research focus is on dissecting the metabolic triggering of insulin secretion and cell survival in pancreatic islets. Methods under development in our lab include: 1) the design of microfluidic devices to hold and assay micro-tissues (e.g. islet-on-a-chip) and 2) the development of genetically encoded sensors to assay cellular metabolism with high spatial and temporal resolution. We aim to use these methods to measure cellular metabolic heterogeneity to determine the effect on tissue function and survival.