Lab Interests:
Current projects in the laboratory fall into the following areas areas: metabolic signal transduction in the pancreatic ß-cells, molecular basis of ß-cell compensation and failure in type 2 diabetes, fuel detoxification process, novel targets for obesity, metabolic syndrome and healthy aging and finally metabolism and cancer. The laboratory addresses these investigations using a broad panoply of technologies, including rodent KO models, RNA silencing, metabolomics/proteomics and transcriptomics, in vivo assessment of glucose/lipid metabolism and insulin signaling, as well as biochemical assays. The group works on both basic research and industry funded projects related to drug and biomarkers discovery.