Montreal Clinical Research Institute (IRCM)
In our lab, we are studying the function and regulation of the bone-derived hormone osteocalcin. This hormone controls insulin secretion and beta cell proliferation, as well as insulin sensitivity in peripheral organs. We are currently studying how the post-translational modifications of osteocalcin (glycosylation, carboxylation, etc.) regulate its activity in mice and humans. In addition, we are investigating the mechanism of vitamin K in beta cell and how this influences the development of diabetes. We are examining the function of vitamin K-dependent proteins in insulin secretion and beta cells adaptation to ER stress. Also, we are characterizing novel vitamin K-dependent proteins.