Michael Sefton
University of Toronto
Lab Interests:

Our lab focuses on improving islet transplantation. We have a novel strategy for creating scaffolds using modular components that are then vascularised by endothelial cell seeding. My lab has also been a pioneer in microencapsulation. We have recently created pseudo islets to reengineer the islet for maximum in vivo performance. We also use whole tissue imaging (eg CLARITY) to image whole tissue explants and demonstrate the integration of host and islet micro-vasculatures, key features of an engrafted islet. Additionally, we use a novel material based on methacrylic acid (MAA) to vascularize the subcutaneous space and enable islet transplants.