We are interested in pancreatic islet function and hormone secretion in health and diabetes. Our research has spanned areas that include biophysical characterization of ion channels; intracellular signal transduction and exocytosis; and the cellular regulation of glucagon secretion. With international collaborators, exciting new directions include islet-cell phenotyping by combined patch-clamp and single-cell sequencing; and computational modelling of human islet cell profiles. Our techniques include hormone secretion assays, single cell patch-clamp electrophysiology, and cellular imaging in human islets and transgenic animal models. We also run an in-house human islet isolation, banking, and distribution program called IsletCore.