University of Western Ontario
Our laboratory is interested in understanding the factors that regulate islet beta cell growth and maintain its viability and function in order to create effective strategies for beta cell replacement or regeneration in human diabetics. We employ a multi-species approach that includes unique cells, animal models and cutting-edge technologies. These allow us to study the molecular events controlling pre- and postnatal beta-cell development and maturation, and to characterize optimal culture environments for maintaining islet architecture and function. Our human fetal pancreatic and intestinal tissue bank and microarray database have promoted diabetes research in several national and international institutions.