Lab Interests:
Our lab studies beta-cell injury and its immunological consequences, primarily in the context of human islet transplantation, but also with a view toward the primary inflammatory events associated with autoimmunity. We study antigen and microRNA release in extracellular vesicles, their relation to cellular stress, and their influence on acquired and innate immune responses. We also manage the McGill University Health Centre Human Islet Transplant Laboratory, where human islet preparations are derived for clinical transplantation. Our work benefits from the availability human samples and subjects, and from a variety of analytical platforms.