Discovery and functional analysis of genes contributing to metabolic diseases including obesity, type 2 diabetes, and cardiovascular disease. We are also interested in identifying specific factors that impact multiple aspects of metabolic disease/the metabolic syndrome. We capitalize on the naturally occurring genetic variation between inbred mouse strains to study genetic factors under defined conditions (e.g. nutritional status). Currently our work is focused on the role of PDK1 in the regulation of metabolism, heart and islet function. Other interests include delineating the genetic basis of enhanced insulin secretion in islets from wild-derived inbred strains (PWD, WSB).