{"id":86,"date":"2020-06-09T05:20:28","date_gmt":"2020-06-09T09:20:28","guid":{"rendered":"https:\/\/islets.ca\/?page_id=86"},"modified":"2022-06-10T13:07:04","modified_gmt":"2022-06-10T19:07:04","slug":"publications","status":"publish","type":"page","link":"https:\/\/islets.ca\/publications\/","title":{"rendered":"Collaborative Publications"},"content":{"rendered":"
[et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” module_id=”code” _builder_version=”4.5.1″ background_color=”#f4f4f4″ custom_padding_tablet=”40px||25px|” custom_padding_phone=”||||false|false” transparent_background=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ padding_mobile=”on” column_padding_mobile=”on” disabled_on=”on|on|on” module_class=”bottom-animated et-waypoint” _builder_version=”4.5.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” disabled=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.5.0″ custom_padding=”|50px|||false|false” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n
1. Manialawy Y, Khan SR, Bhattacharjee A, Wheeler MB: The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion. J Biol Chem. , 2020<\/a><\/p>\n 2. Estall JL, Screaton RA: Of mice and men, redux: Modern challenges in beta cell gene targeting. Endocrinology. , 2020<\/p>\n 3. Turcotte A, Grenier-Larouche T, Lacombe J, Carreau A, Carpentier AC, Mac-Way F, Tchernof A, Richard D, Biertho L, Lebel S, Marceau S, Ferron M, Gagnon C: Association between changes in bioactive osteocalcin and glucose homeostasis after biliopancreatic diversion. Endocrine. , 2020<\/p>\n 4. Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE, Philippaert K, Light PE: Human islets contain a subpopulation of glucagon-like peptide-1 secreting \u03b1 cells that is increased in type 2 diabetes. Mol Metab. :101014, 2020<\/p>\n 5. Camunas-Soler J, Dai X, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE: Patch-seq links single-cell transcriptomes to human islet dysfunction in diabetes. Cell Metab. 31:1017-1031.e4, 2020<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.0″ custom_padding=”|||50px|false|false” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n 6. Chen Y, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB: Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice. Diabetologia. 63:1090, 2020<\/p>\n 7. Ludwig DS, Ebbeling CB, Bikman BT, Johnson JD: Testing the carbohydrate-insulin model in mice: The importance of distinguishing primary hyperinsulinemia from insulin resistance and metabolic dysfunction. Mol Metab. 35:100960, 2020<\/p>\n 8. Colomba J, Rabasa-Lhoret R, Bonhoure A, Bergeron C, Boudreau V, Tremblay F, Senior P, Potter K: Dyslipidemia is not associated with the development of glucose intolerance or diabetes in cystic fibrosis. J Cyst Fibros. , 2020<\/p>\n 9. Ramzy A, Asadi A, Kieffer TJ: Revisiting proinsulin processing: Evidence that human \u03b2-cells process proinsulin with prohormone convertase (PC) 1\/3 but not PC2. Diabetes. , 2020<\/p>\n 10. Misra PS, Nostro MC: Islet-resident endocrine progenitors: A new hope for beta cell PROCReation? Cell Stem Cell. 26:471-473, 2020<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs _builder_version=”4.14.7″ _module_preset=”default” custom_padding=”|4em||4em|true|true” hover_enabled=”0″ border_width_all=”0px” global_colors_info=”{}” sticky_enabled=”0″][et_pb_tab title=”2022″ _builder_version=”4.14.7″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Ramzy A, Edeer N, Baker RK, O’Dwyer S, Mojibian M, Verchere CB<\/span>,\u00a0Kieffer TJ.<\/span> Insulin Null \u03b2-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression. Endocrinology. 2022 Jun 1;163(6):bqac051<\/a>.<\/p>\n Nguyen-Tu MS, Harris J, Martinez-Sanchez A, Chabosseau P, Hu M, Georgiadou E, Pollard A, Otero P, Lopez-Noriega L, Leclerc I<\/span>, Sakamoto K, Schmoll D, Smith DM, Carling D, Rutter GA<\/span>. Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase. Diabetologia. 2022 Jun;65(6):997-1011.<\/a><\/p>\n Verhoeff K, Marfil-Garza BA, Sandha G, Cooper D, Dajani K, Bigam DL, Anderson B, Kin T<\/span>, Lam A, O’Gorman D, Senior PA, Ricordi C, Shapiro AMJ<\/span>. Outcomes Following Extrahepatic and Intraportal Pancreatic Islet Transplantation: A Comparative Cohort Study. Transplantation. 2022 Jun 1.<\/a><\/p>\n Akalestou E, Lopez-Noriega L, Tough IR, Hu M, Leclerc I, Cox HM, Rutter GA<\/span>. Vertical Sleeve Gastrectomy Lowers SGLT2\/Slc5a2 Expression in the Mouse Kidney. Diabetes. 2022 May 20;db210768.<\/a><\/p>\n Marfil-Garza BA, Imes S, Verhoeff K, Hefler J, Lam A, Dajani K, Anderson B, O’Gorman D, Kin T<\/span>, Bigam D, Senior PA, Shapiro AMJ.<\/span> Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada. Lancet Diabetes Endocrinol. 2022 May 16;S2213-8587(22):00114-0.<\/a><\/p>\n Georgiadou E, Muralidharan C, Martinez M, Chabosseau P, Akalestou E, Tomas A, Yong Su Wern F, Stylianides T, Wretlind A, Legido-Quigley C, Jones B, Lopez Noriega L, Xu Y, Gu G, Alsabeeh N, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I<\/span>, Ali Y, Soleimanpour SA, Linnemann AK, Rodriguez TA,\u00a0Rutter GA.<\/span> Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion. Diabetes. 2022 Apr 26;db210800.<\/a><\/p>\n Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Tapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J<\/span>, Piemonti L, de Koning E, Leclerc I<\/span>, Bouzakri K, Sakamoto K, Smith DM, Rutter GA<\/span>, Martinez-Sanchez A. Glucose-Dependent miR-125b is a Negative Regulator of \u03b2-Cell Function. Diabetes. 2022 Apr 27;db210803.<\/a><\/p>\n Mugabo Y, Zhao C, Tan JJ, Ghosh A, Campbell SA, Fadzeyeva E, Par\u00e9 F, Pan SS, Galipeau M, Ast J, Broichhagen J, Hodson DJ, Mulvihill EE<\/span>, Petropoulos S, Lim GE<\/span>. 14-3-3\u03b6 Constrains insulin secretion by regulating mitochondrial function in pancreatic \u03b2 cells. JCI Insight. 2022 Apr 22;7(8):e156378.<\/a><\/p>\n Kin T<\/span>, Shapiro AJ<\/span>. Reassessment of the embryonic fusion plane between the ventral and dorsal pancreases in human donors for transplantation. Pancreatology. 2022 Apr;22(3):446-447.<\/a><\/p>\n Kuppan P, Kelly S, Seeberger K, Castro C, Rosko M, Pepper AR<\/span>,\u00a0Korbutt GS<\/span>. Bioabsorption of Subcutaneous Nanofibrous Scaffolds Influences the Engraftment and Function of Neonatal Porcine Islets. Polymers (Basel). 2022 Mar 11;14(6):1120.<\/a><\/p>\n Yung JHM, Yeung LSN, Ivovic A, Tan YF, Jentz EM, Batchuluun B, Gohil H, Wheeler MB<\/span>, Joseph JW<\/span>, Giacca A<\/span>, Mamelak M. Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate. Cells. 2022 Feb 4;11(3):545<\/a><\/p>\n Zhang AMY, Chu KH, Daly BF, Ruiter T, Dou Y, Yang JCC, de Winter TJJ, Chhuor J, Wang S, Flibotte S, Zhao YB, Hu X, Li H, Rideout EJ<\/span>, Schaeffer DF, Johnson JD<\/span>, Kopp JL<\/span>. Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics. Cancer Metab. 2022 Feb 21;10(1):5.<\/a><\/p>\n Skovs\u00f8 S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-M\u00e9neur C, Flibotte S, Sinha S, Luciani DS<\/span>, Nislow C, Rideout EJ<\/span>, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE<\/span>, Johnson JD<\/span>. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nat Commun. 2022 Feb 8;13(1):735.<\/a><\/p>\n Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE<\/span>, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE<\/span>. Heterogenous impairment of \u03b1 cell function in type 2 diabetes is linked to cell maturation state. Cell Metab. 2022 Feb 1;34(2):256-268.e5.<\/a><\/p>\n Linnemann AK, Poitout V<\/span>, Rutter GA<\/span>. Editorial: Pancreas Imaging Across the Spectrum. Front Endocrinol (Lausanne). 2021 Jan 3;12:832519. <\/a><\/p>\n [\/et_pb_tab][et_pb_tab title=”2021″ _builder_version=”4.14.7″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Nahle A, Joseph YD, Pereira S, Mori Y, Poon F, Ghadieh HE, Ivovic A, Desai T, Ghanem SS, Asalla S, Muturi HT, Jentz EM, Joseph JW<\/span>, Najjar SM, Giacca A<\/span>. Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance. Int J Mol Sci. 2021 Dec 8;22(24):13224<\/a><\/p>\n Dos Santos T, Galipeau M, Schukarucha Gomes A, Greenberg M, Larsen M, Lee D, Maghera J, Mulchandani CM, Patton M, Perera I, Polishevska K, Ramdass S, Shayeganpour K, Vafaeian K, Van Allen K, Wang Y, Weisz T,\u00a0Estall JL<\/span>, Mulvihill EE<\/span>, Screaton RA<\/span>; Diabetes Action Canada and the Canadian Islet Research and Training Network. Islet Biology During COVID-19: Progress and Perspectives. Can J Diabetes. 2021 Nov 23;S1499-2671(21):00440-8.<\/a><\/p>\n Hoesli CA<\/span>, Kieffer TJ<\/span>. Pancreatic islets in bed with microvasculature-companions for life. Cell Rep Med. 2021 Nov 16;2(11):100454.<\/a><\/p>\n Erener S, Ellis CE, Ramzy A, Glavas MM, O’Dwyer S, Pereira S, Wang T, Pang J, Bruin JE,<\/span> Riedel MJ, Baker RK, Webber TD, Lesina M, Bl\u00fcher M, Alg\u00fcl H, Kopp JL<\/span>, Herzig S, Kieffer TJ<\/span>. Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice. Cell Rep Med. 2021 Nov 11;2(11):100434.<\/a><\/p>\n Cefalu WT, Andersen DK, Arreaza-Rub\u00edn G, Pin CL, Sato S, Verchere CB<\/span>, Woo M<\/span>, Rosenblum ND; symposium planning committee, moderators, and speakers; Symposium planning committee, moderators, and speakers:. Heterogeneity of Diabetes: \u03b2-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 Nov 13:db210777.<\/a><\/p>\n Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T<\/span>, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ<\/span>, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 Nov 23;37(8):110037<\/a><\/p>\n Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Alghamdi TA, Lewandowski SL, Jin Y, Bautista A, Wang YW, Manning Fox JE, Merrins MJ, Buteau J<\/span>, MacDonald PE<\/span>. \u03b2-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High Fat Diet-Fed Mice. Diabetes. 2021 Nov;70(11):2626-2638.<\/a><\/p>\n Wong HY, Hui Q, Hao Z, Warnock GL, Woo M<\/span>, Luciani DS<\/span>, Marzban L<\/span>. The role of mitochondrial apoptotic pathway in islet amyloid-induced \u03b2-cell death. Mol Cell Endocrinol. 2021 Nov 1;537:111424.<\/a><\/p>\n Pasula DJ, Shi R, Vanderkruk B, Shih AZL, Zou Y, Chaudhry A, Hoffman BG<\/span>, Luciani DS<\/span>. Bcl-xL restricts transcriptional, morphological and functional decompensation of \u03b2-cell mitochondria under chronic glucose excess. bioRxiv 2021.10.25.465491<\/a><\/p>\n Modi H, Chu CMJ, Skovs\u00f8 S, Ellis C, Krentz NAJ, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ<\/span>, Lynn FC<\/span>, Johnson JD<\/span>. Dynamic Ins2 gene activity defines \u03b2 cell maturity states. bioRxiv 702589<\/a><\/p>\n Jouvet N, Bouyakdan K, Campbell SA, Baldwin C, Townsend SE, Gannon MA, Poitout V<\/span>, Alquier T, Estall JL<\/span>. The Tetracycline-Controlled Transactivator (Tet-On\/Off) System in Beta Cells Reduces Insulin Expression and Secretion in Mice. Diabetes. 2021 Oct 5:db210147<\/a><\/p>\n Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T<\/span>, Shapiro AMJ<\/span>, Chew RSE, Keong Teo AK, Oyadomari S, Terauchi Y, Shirakawa J. Imeglimin ameliorates \u03b2-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway. Diabetes. 2021 Sep 29:db210123.<\/a><\/p>\n Glavas MM, Hui Q, Miao I, Yang F, Erener S, Prentice KJ, Wheeler MB<\/span>, Kieffer TJ<\/span>. Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats. Sci Rep. 2021 Jul 7;11(1):14032.<\/a><\/p>\n Iorio C, Rourke JL, Wells L, Sakamaki JI, Moon E, Hu Q, Kin T<\/span>, Screaton RA<\/span>. Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human \u03b2 cell proliferation. Commun Biol. 2021 Jul 23;4(1):907.<\/a><\/p>\n Marfil-Garza BA, Hefler J, Dajani K, Kin T<\/span>, Shapiro AMJ<\/span>. Total pancreatectomy with islet cell autotransplantation in a 2-year-old child with hereditary pancreatitis due to a PRSS1 mutation. Am J Transplant. 2021 Jun 16.<\/a><\/p>\n Xu J, Wijesekara N, Regeenes R, Rijjal DA, Piro AL, Song Y, Wu A, Bhattacharjee A, Liu Y, Marzban L<\/span>, Rocheleau JV<\/span>, Fraser PE, Dai FF, Hu C, Wheeler MB<\/span>. Pancreatic \u03b2 cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis. JCI Insight. 2021 May 24;6(10):143037<\/a><\/p>\n Kim MJ, Febbraro D, Farkona S, Gillmore T, Son JE, Regeenes R, Chang HH, Pollock-Tahiri E, Yang J, Park YJ, Sivasubramaniyam T, Oh SJ, Saraon P, Stagljar I, Rocheleau JV<\/span>, Hui CC, Caniggia I, Hao Z, Mak TW, Konvalinka A, Woo M<\/span>: Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis. Mol Metab. May;47:101185, 2021<\/a><\/p>\n Wang S, Flibotte S, Camunas-Soler J, MacDonald PE<\/span>, Johnson JD<\/span>. A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data. Can J Diabetes. 2021 Dec;45(8):775-784.e2<\/a><\/p>\n Pepper AR<\/span>, Korbutt GS<\/span>. Conditioning the liver into a favorable niche for pancreatic islet engraftment. Am J Transplant. 2021 Mar 30<\/a>.<\/p>\n Zhang AMY, Wellberg EA, Kopp JL<\/span><\/span>, Johnson JD<\/span><\/span>: Hyperinsulinemia in Obesity, Inflammation, and Cancer. Diabetes Metab J. Mar 29, 2021<\/a><\/p>\n Campbell SA<\/span><\/span> , Janyne Johnson , Light PE<\/span><\/span>: Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1. Islets Mar 16:1-19, 2021<\/a><\/p>\n Panzhinskiy E, Skovs\u00f8 S, Cen HH, Chu KY, MacDonald K, Soukhatcheva G, Dionne DA, Hallmaier-Wacker LK, Wildi JS, Marcil S, Noursadeghi N, Taghizadeh F, Verchere CB<\/span><\/span>, Jan E, Johnson JD<\/span><\/span>: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition. bioRxiv 2021.02.17.431676<\/a><\/p>\n Vanderkruk B, Maeshima N, Pasula DJ, An M, Suresh P, Daniel A, McDonald CL, Luciani DS<\/span>, Hoffman BG<\/span>: H3K4 Methylation in \u03b2-cells Prevents Transcriptional Downregulation and Variance Associated with Type 2 Diabetes. bioRxiv 2021.01.28.428651<\/a><\/p>\n [\/et_pb_tab][et_pb_tab title=”2020″ _builder_version=”4.14.7″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Ramzy A, Tudur\u00ed E, Glavas MM, Baker RK, Mojibian M, Fox JK, O’Dwyer SM, Dai D, Hu X, Denroche HC, Edeer N, Gray SL, Verchere CB<\/span>, Johnson JD<\/span>, Kieffer TJ<\/span>: AAV8 Ins1-cre can produce efficient \u03b2-cell recombination but requires consideration of off-target effects. Sci Rep. 10:10518, 2020<\/a><\/p>\n Estall JL<\/span>, Screaton RA<\/span>: Of mice and men, redux: Modern challenges in beta cell gene targeting. Endocrinology. , 2020<\/a><\/p>\n Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE<\/span>, Philippaert K, Light PE<\/span>: Human islets contain a subpopulation of glucagon-like peptide-1 secreting \u03b1 cells that is increased in type 2 diabetes. Mol Metab. 39:101014, 2020<\/a><\/p>\n Lacombe J, Al Rifai O, Loter L, Moran T, Turcotte A, Grenier-Larouche T, Tchernof A, Biertho L, Carpentier AC, Prud’homme D, Rabasa-Lhoret R<\/span>, Karsenty G, Gagnon C, Jiang W, Ferron M<\/span>: Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and \u03b2-cell function. Am J Physiol Endocrinol Metab. 318:E381-E391, 2020<\/a><\/p>\n Chen Y, Mains RE, Eipper BA, Hoffman BG<\/span>, Czyzyk TA, Pintar JE, Verchere CB<\/span>: PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice. Diabetologia. 63:561-576, 2020<\/a><\/p>\n Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson C, Kieffer TJ<\/span>, Banks K, Pessin JE, Gaisano HY<\/span>: SNAP23 depletion enables more SNAP25\/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes. JCI Insight. 5, 2020<\/a><\/p>\n [\/et_pb_tab][et_pb_tab title=”2019″ _builder_version=”4.6.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O’Shannessy DJ, Zheng X, Catrina S, Albone E, Laine J, Virtanen K, Clee SM<\/span>, Kieffer TJ<\/span>, Noll C, Carpentier AC, Johnson JD<\/span>, Ryd\u00e9n M, Conway EM: Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine. 44:489-501, 2019<\/a><\/p>\n Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Fox JEM, Gaisano HY<\/span>, MacDonald P<\/span>E: A glucose-dependent spatial patterning of exocytosis in human \u03b2-cells is disrupted in type 2 diabetes. JCI Insight. 5, 2019<\/a><\/p>\n Desai T, Koulajian K, Ivovic A, Breen DM, Luu L, Tsiani EL, Wheeler MB<\/span>, Giacca A<\/span>: Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo. Nutr Diabetes. 9:11, 2019<\/a><\/p>\n Campbell SA, McDonald CL, Krentz NAJ, Lynn FC<\/span>, Hoffman BG<\/span>: TrxG complex catalytic and non-catalytic activity play distinct roles in pancreas progenitor specification and differentiation. Cell Rep. 28:1830-1844.e6, 2019<\/a><\/p>\n Poitout V<\/span>, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB<\/span>, Herold KC, Myers MG, Marshall SM: A call for improved reporting of human islet characteristics in research articles. Diabetes. 68:239-240, 2019<\/a><\/p>\n Tudur\u00ed E, Glavas MM, Asadi A, Baker RK, Ellis CE, Soukhatcheva G, Philit M, Huynh FK, Johnson JD<\/span>, Bruce Verchere C<\/span>, Kieffer TJ<\/span>: AAV GCG-EGFP, a new tool to identify glucagon-secreting \u03b1-cells. Sci Rep. 9:10829, 2019<\/a><\/p>\n Pepper AR<\/span>, Bruni A, Pawlick R, O’Gorman D, Kin T<\/span>, Thiesen A, Shapiro AMJ: Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts. Diabetes. 68(5):953-962, 2019<\/a><\/p>\n Glavas MM, Hui Q, Tudur\u00ed E, Erener S, Kasteel NL, Johnson JD<\/span>, Kieffer TJ<\/span>: Early overnutrition reduces Pdx1 expression and induces \u03b2 cell failure in swiss webster mice. Sci Rep. 9:3619, 2019<\/a><\/p>\n Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J<\/span>, Dai FF\u00a0 Wheeler MB<\/span>: GABA promotes \u03b2-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity. FASEB J. 33:3968-3984, 2019<\/a><\/p>\n Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V<\/span>, MacDonald PE<\/span>: A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiol Rep. 7:e14250, 2019<\/a><\/p>\n Pereira S, O’Dwyer SM, Webber TD, Baker RK, So V, Ellis CE, Yoon JS, Mojibian M, Glavas MM, Karunakaran S, Clee SM<\/span>, Covey SD, Kieffer TJ<\/span>: Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues. Sci Rep. 9:3307, 2019<\/a><\/p>\n Zhang AMY, Magrill J, de Winter, Twan J. J., Hu X, Skovs\u00f8 S, Schaeffer DF, Kopp JL<\/span>, Johnson JD<\/span>: Endogenous hyperinsulinemia contributes to pancreatic cancer development. Cell Metab. 30:403-404, 2019<\/a><\/p>\n [\/et_pb_tab][et_pb_tab title=”2018″ _builder_version=”4.5.3″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang C, Sagar n, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin SH, Lynn FC<\/span>, Hoffman BG<\/span>, Gr\u00fcn D, Vavouri T, Lempradl AM, Pospisilik JA: The polycomb-dependent epigenome controls \u03b2 cell dysfunction, dedifferentiation, and diabetes. Cell Metab. 27:1294-1308.e7, 2018<\/a><\/p>\n