Collaborative Publications

Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND; symposium planning committee, moderators, and speakers; Symposium planning committee, moderators, and speakers:. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 Nov 15:db210777.

Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 Nov 23;37(8):110037

Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Alghamdi TA, Lewandowski SL, Jin Y, Bautista A, Wang YW, Manning Fox JE, Merrins MJ, Buteau J, MacDonald PE. β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High Fat Diet-Fed Mice. Diabetes. 2021 Nov;70(11):2626-2638.

Wong HY, Hui Q, Hao Z, Warnock GL, Woo M, Luciani DS, Marzban L. The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death. Mol Cell Endocrinol. 2021 Nov 1;537:111424.

Pasula DJ, Shi R, Vanderkruk B, Shih AZL, Zou Y, Chaudhry A, Hoffman BG, Luciani DS. Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess. bioRxiv 2021.10.25.465491

Modi H, Chu CMJ, Skovsø S, Ellis C, Krentz NAJ, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD. Dynamic Ins2 gene activity defines β cell maturity states. bioRxiv 702589

Mugabo Y, Zhao C, Tan JJ,  Ghosh A, Campbell SA, Fadzeyeva E, Paré F, Pan SS, Galipeau M, Ast J,  Broichhagen J, Hodson DJ, Mulvihill EE, Petropoulos S, Lim GE.14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cells. bioRxiv 2021.10.17.464702

Jouvet N, Bouyakdan K, Campbell SA, Baldwin C, Townsend SE, Gannon MA, Poitout V, Alquier T, Estall JL. The Tetracycline-Controlled Transactivator (Tet-On/Off) System in Beta Cells Reduces Insulin Expression and Secretion in Mice. Diabetes. 2021 Oct 5:db210147

Li J, Inoue R, Togashi Y, Okuyama T, Satoh A, Kyohara M, Nishiyama K, Tsuno T, Miyashita D, Kin T, Shapiro AMJ, Chew RSE, Keong Teo AK, Oyadomari S, Terauchi Y, Shirakawa J. Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway. Diabetes. 2021 Sep 29:db210123.

Glavas MM, Hui Q, Miao I, Yang F, Erener S, Prentice KJ, Wheeler MB, Kieffer TJ. Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats. Sci Rep. 2021 Jul 7;11(1):14032.

Iorio C, Rourke JL, Wells L, Sakamaki JI, Moon E, Hu Q, Kin T, Screaton RA. Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation. Commun Biol. 2021 Jul 23;4(1):907.

Marfil-Garza BA, Hefler J, Dajani K, Kin T, Shapiro AMJ. Total pancreatectomy with islet cell autotransplantation in a 2-year-old child with hereditary pancreatitis due to a PRSS1 mutation. Am J Transplant. 2021 Jun 16.

Xu J, Wijesekara N, Regeenes R, Rijjal DA, Piro AL, Song Y, Wu A, Bhattacharjee A, Liu Y, Marzban L, Rocheleau JV, Fraser PE, Dai FF, Hu C, Wheeler MB. Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis. JCI Insight. 2021 May 24;6(10):143037

Kim MJ, Febbraro D, Farkona S, Gillmore T, Son JE, Regeenes R, Chang HH, Pollock-Tahiri E, Yang J, Park YJ, Sivasubramaniyam T, Oh SJ, Saraon P, Stagljar I, Rocheleau JV, Hui CC, Caniggia I, Hao Z, Mak TW, Konvalinka A, Woo M: Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis. Mol Metab. May;47:101185, 2021

Wang S, Flibotte S, Camunas-Soler J, MacDonald PE, Johnson JD: A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data. CJD accepted

Pepper AR, Korbutt GS. Conditioning the liver into a favorable niche for pancreatic islet engraftment. Am J Transplant. 2021 Mar 30.

Zhang AMY, Wellberg EA, Kopp JL, Johnson JD: Hyperinsulinemia in Obesity, Inflammation, and Cancer. Diabetes Metab J. Mar 29, 2021

Campbell SA , Janyne Johnson , Light PE: Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1. Islets Mar 16:1-19, 2021

Zhang AMY, de Winter TJJ, Wang S, Flibotte S, Zhao YB, Hu X, Li H, Schaeffer DF, Johnson JD, Kopp JL: Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics. bioRxiv 2021.03.10.434504

Panzhinskiy E, Skovsø S, Cen HH, Chu KY, MacDonald K, Soukhatcheva G, Dionne DA, Hallmaier-Wacker LK, Wildi JS, Marcil S, Noursadeghi N, Taghizadeh F, Verchere CB, Jan E, Johnson JD: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition. bioRxiv 2021.02.17.431676

Vanderkruk B, Maeshima N, Pasula DJ, An M, Suresh P, Daniel A, McDonald CL, Luciani DS, Hoffman BG: H3K4 Methylation in β-cells Prevents Transcriptional Downregulation and Variance Associated with Type 2 Diabetes. bioRxiv 2021.01.28.428651

Skovsø S, Panzhinskiy E, Kolic J, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Cen HH, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi J, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim J, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD: Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion. bioRxiv 2020.10.15.338160

Ramzy A, Tudurí E, Glavas MM, Baker RK, Mojibian M, Fox JK, O’Dwyer SM, Dai D, Hu X, Denroche HC, Edeer N, Gray SL, Verchere CB, Johnson JD, Kieffer TJ: AAV8 Ins1-cre can produce efficient β-cell recombination but requires consideration of off-target effects. Sci Rep. 10:10518, 2020

Estall JL, Screaton RA: Of mice and men, redux: Modern challenges in beta cell gene targeting. Endocrinology. , 2020

Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE, Philippaert K, Light PE: Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes. Mol Metab. 39:101014, 2020

Lacombe J, Al Rifai O, Loter L, Moran T, Turcotte A, Grenier-Larouche T, Tchernof A, Biertho L, Carpentier AC, Prud’homme D, Rabasa-Lhoret R, Karsenty G, Gagnon C, Jiang W, Ferron M: Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function. Am J Physiol Endocrinol Metab. 318:E381-E391, 2020

Chen Y, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB: PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice. Diabetologia. 63:561-576, 2020

Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson C, Kieffer TJ, Banks K, Pessin JE, Gaisano HY: SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes. JCI Insight. 5, 2020

Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O’Shannessy DJ, Zheng X, Catrina S, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM: Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine. 44:489-501, 2019

Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Fox JEM, Gaisano HY, MacDonald PE: A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. JCI Insight. 5, 2019

Desai T, Koulajian K, Ivovic A, Breen DM, Luu L, Tsiani EL, Wheeler MB, Giacca A: Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo. Nutr Diabetes. 9:11, 2019

Campbell SA, McDonald CL, Krentz NAJ, Lynn FC, Hoffman BG: TrxG complex catalytic and non-catalytic activity play distinct roles in pancreas progenitor specification and differentiation. Cell Rep. 28:1830-1844.e6, 2019

Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG, Marshall SM: A call for improved reporting of human islet characteristics in research articles. Diabetes. 68:239-240, 2019

Tudurí E, Glavas MM, Asadi A, Baker RK, Ellis CE, Soukhatcheva G, Philit M, Huynh FK, Johnson JD, Bruce Verchere C, Kieffer TJ: AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells. Sci Rep. 9:10829, 2019

Pepper AR, Bruni A, Pawlick R, O’Gorman D, Kin T, Thiesen A, Shapiro AMJ: Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts. Diabetes. 68(5):953-962, 2019

Glavas MM, Hui Q, Tudurí E, Erener S, Kasteel NL, Johnson JD, Kieffer TJ: Early overnutrition reduces Pdx1 expression and induces β cell failure in swiss webster mice. Sci Rep. 9:3619, 2019

Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF  Wheeler MB: GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity. FASEB J. 33:3968-3984, 2019

Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE: A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiol Rep. 7:e14250, 2019

Pereira S, O’Dwyer SM, Webber TD, Baker RK, So V, Ellis CE, Yoon JS, Mojibian M, Glavas MM, Karunakaran S, Clee SM, Covey SD, Kieffer TJ: Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues. Sci Rep. 9:3307, 2019

Zhang AMY, Magrill J, de Winter, Twan J. J., Hu X, Skovsø S, Schaeffer DF, Kopp JL, Johnson JD: Endogenous hyperinsulinemia contributes to pancreatic cancer development. Cell Metab. 30:403-404, 2019

Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang C, Sagar n, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin SH, Lynn FC, Hoffman BG, Grün D, Vavouri T, Lempradl AM, Pospisilik JA: The polycomb-dependent epigenome controls β cell dysfunction, dedifferentiation, and diabetes. Cell Metab. 27:1294-1308.e7, 2018

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ: BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. Am J Transplant. 18(8):1879-1889, 2018

Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Flibotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD: Reducing insulin via conditional partial gene ablation in adults reverse diet-induced weight gain. FASEB J. 32:1196-1206, 2018

Sabatini PV, Speckmann T, Nian C, Glavas MM, Wong CK, Yoon JS, Kin T, Shapiro AMJ, Gibson WT, Verchere CB, Lynn FC: Neuronal PAS domain protein 4 suppression of oxygen sensing optimizes metabolism during excitation of neuroendocrine cells. Cell Rep. 22:163-174, 2018

Yu Y, Gamble A, Pawlick R, Pepper AR, Salama B, Toms D, Razian G, Ellis C, Bruni A, Gala-Lopez B, Lu JL, Vovko H, Chiu C, Abdo S, Kin T, Korbutt G, Shapiro AMJ, Ungrin M: Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice. Diabetologia. 61(9):2016-2029, 2018

Wong CK, Wade-Vallance AK, Luciani DS, Brindle PK, Lynn FC, Gibson WT: The p300 and CBP transcriptional coactivators are required for β-cell and α-cell proliferation. Diabetes. 67:412-422, 2018

Saber N, Bruin JE, O’Dwyer S, Schuster H, Rezania A, Kieffer TJ: Sex differences in maturation of human embryonic stem cell-derived β cells in mice. Endocrinology. 159:1827-1841, 2018

Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A: N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes. Cell Metab. 25:1334-1347.e4, 2017

Bonneau J, Ferland G, Karelis AD, Doucet É, Faraj M, Rabasa-Lhoret R, Ferron M: Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women. J Diabetes Complicat. 31:1027-1034, 2017

Hamza SM, Sung MM, Gao F, Soltys CM, Smith NP, MacDonald PE, Light PE, Dyck JRB: Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. Biochim Biophys Acta Gen Subj. 1861:313-322, 2017

Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B: Heparanase overexpression induces glucagon resistance and protects animals from chemically induced diabetes. Diabetes. 66:45-57, 2017

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE: Kv2.1 clustering contributes to insulin exocytosis and rescues human β-cell dysfunction. Diabetes. 66:1890-1900, 2017

Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O’Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ: Transplantation of human pancreatic endoderm cells reverses diabetes post transplantation in a prevascularized subcutaneous site. Stem Cell Reports. 8:1689-1700, 2017

Liang T, Qin T, Xie L, Dolai S, Zhu D, Prentice KJ, Wheeler M, Kang Y, Osborne L, Gaisano HY: New roles of syntaxin-1A in insulin granule exocytosis and replenishment. J Biol Chem. 292:2203-2216, 2017

Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A: IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 60:2021-2032, 2017

Seshadri N, Jonasson ME, Hunt KL, Xiang B, Cooper S, Wheeler MB, Dolinsky VW, Doucette CA: Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice. Mol Metab. 6:760-769, 2017

Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L: Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets. Mol Metab. 6:833-844, 2017

Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L: Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation. Diabetes Obes Metab. 19:682-694, 2017

Templeman NM, Flibotte S, Chik JHL, Sinha S, Lim GE, Foster LJ, Nislow C, Johnson JD: Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. Cell Rep. 20:451-463, 2017

Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD: A causal role for hyperinsulinemia in obesity. J Endocrinol. 232:R173-R183, 2017

Pepper AR, Bruni A, Pawlick R, Wink J, Rafiei Y, Gala-Lopez B, Bral M, Abualhassan N, Kin T, Shapiro AMJ. Engraftment Site and Effectiveness of the Pan-Caspase Inhibitor F573 to Improve Engraftment in Mouse and Human Islet Transplantation in Mice. Transplantation. 101(10):2321-2329, 2017

Pawlick R, Gala-Lopez B, Pepper AR, Abualhassan N, Bruni A, Suzuki K, Rayat G, Elliott JF, Shapiro AMJ: Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations. Islets. 9:e1330742, 2017

Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC: Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun. 8:331, 2017